How To Install BioPerl on Mac OS X Snow Leopard
BioPerl is a collection of Perl modules that facilitate the development of Perl scripts for bioinformatics applications.  The easiest way to install it on Mac OS X was to use fink, because BioPerl requires many other perl modules preinstalled and fink automatically installs them.  Until Mac OS X 10.5 Leopard, fink binary package and BioPerl binary package for fink were available and it was pretty easy to install BioPerl.  However, fink binary package is not available for Mac OS X 10.6 Snow Leopard as of today and it is not easy to install BioPerl on Snow Leopard.
This page describes how to install fink and BioPerl on Mac OS X 10.6 Snow Leopard.  Both of them are built from the source codes.
 
The procedure  below was confirmed to work fine on Mac OS X 10.6.4 Snow Leopard.
 
If you want to install BioPerl on Mac OS X 10.5 or earlier, you don't have to follow the procedure below.  Just install fink and BioPerl binaries.  Instruction is found here.
 
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Up-to-date as of 10/23/2010

 
 
1. Preparation
1.1. Install Xcode 3.2 or later on your Mac.  Xcode is found in the Mac OS X Installation DVD or you can download it from http://developer.apple.com/technologies/xcode.html with free Apple Developer membership.
2. Install fink  Original installation instruction is here
2.1. Download fink-0.29.14.tar.gz from http://www.finkproject.org/download/srcdist.php
2.2. Open Applications/Utilities/Terminal and enter commands below.
2.3. tar xfz fink-0.29.14.tar.gz
2.4. cd fink-0.29.14
2.5. ./bootstrap
          It will ask many questions.  Accept default values.
2.6. /sw/bin/pathsetup.sh
          It will setup environment for fink.
2.7. fink selfupdate-rsync
2.8. fink index -f
3. Install BioPerl
3.1. fink configure
          Accept default values except 'The "unstable" tree does not appear to be activated
          in your fink now. Do you want to activate it? [y/N] ' Answer y for this.
3.2. fink selfupdate.
          Accept default values.
3.3. fink selfupdate-rsync
3.4. fink index -f
3.5. fink scanpackages
3.6. fink list
          Find Package Name.  The most recent one for Snow Leopard is bioperl-pm5100
3.7. fink install bioperl-pm5100
          Accept default values.  This will install BioPerl and required perl modules from source codes.
 
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